Biguanides have the ability to regulate sugar levels in the blood.
They have anti hyperglycemic, lowering both basal and postprandial, they do not stimulate insulin secretion and therefore does not cause hypoglycemia.
Biguanides are intended for non-insulin dependent diabetes, and are administered orally.
Biguanides may act via three mechanisms:
Their action, however, requires the presence of endogenous or exogenous insulin.
Absorption, and elimination half-life of a product are important parameters because they determine the mode of administration of the product and the number of daily doses to maintain efficacy.
These pharmacokinetic parameters permit the administration of these products with 2 to 3 times per day with meals.
Prescription biguanides aims to:
Biguanides are the first-line drug for type II diabetes, non-insulin dependent.
They are also used in diabetes already treated with insulin in addition to insulin.
These are some complications that can occur when taking the drug, knowing that induced side effects vary among individuals.
When taking biguanide were reported:
It is recommended to discontinue treatment with biguanide 2 days before and after surgical or radiological examinations with iodinated contrast media.
We need to take insulin if surgery or other causes of decompensation of diabetes.
During pregnancy, diabetes should be treated with insulin.
About breastfeeding: either stop breastfeeding or stopping treatment with biguanide.
Biguanides do not cause hypoglycemia by themselves, but it should be remembered that hypoglycemic events (palpitations, nausea, blurred vision, loss of the ability to perform a task …) may occur in case of associations with other hypoglycemic, which can compromise driving and operating machinery.
Taking a drug can lead to propose some precautions in the management of everyday life.
The early and active participation of the patient in his care is essential